John Gordon Knowledge Transfer

Knowledge Transfer - Patents

Publications Since 2004: 19

73. J.R Gordon, X. Zhang, and F. Li. 2009.  Amelioration of pathology in a swine model of airway endotoxin exposure by ELR-CXC chemokine antagonism. Journal of Agromedicine, in press

72. E. Bagu, J.R. Gordon, and N. Rawlings.  2009.  Postnatal changes in testicular concentrations of interleukin-1 alpha and beta and interleukin-6 during sexual maturation in bulls. Journal of Domestic Animal Reproduction (Jan 8. [Epub ahead of print]).

71. X. Zhao, J.R. Town, F. Li, X. Zhang, D. Cockcroft, and J.R. Gordon.  2009.  ELR-CXC chemokine receptor antagonism targets inflammatory responses at multiple levels. Journal of Immunology 182:3213-22.

70. E. Bagu, J.R. Gordon, and N. Rawlings.  2009.  Postnatal changes in serum concentrations of insulin like growth factor-1 and testicular concentrations of transformation growth factors alpha and beta-1, -2 and -3 in bulls. Journal of Domestic Animal Reproduction (Jan 21. [Epub ahead of print]).

69. S. Hao, J. Yuan, S. Xu, M.A. Munegowda, Y. Deng, J.R. Gordon, Z. Xing, and J. Xiang.  2008. Antigen specificity acquisition of adoptive CD4+ regulatory T cells via acquired peptide-MHC class I complexes.  Journal of Immunology 181:2428-37.

68. H-T Cheng, K-C Huang, H-Y Yu, K-J Gao, X. Zhao, F. Li, J. Town, J.R. Gordon, J-W Cheng.  2008. A new protocol for high-yield purification of recombinant human CXCL8(3–72)K11R/G31P expressed in Escherichia coli. Protein Expression and Purification 61:65-72.

67. N. Podechard, V. Lecureur, E. Leferrec,  I. Guenon, L. Sparfel, D. Gilot, J.R. Gordon, V. Lagente, & O. Fardel. 2008.  Interleukin-8 induction by the environmental contaminant benzo(a)pyrene is aryl hydrocarbon receptor-dependent and leads to lung inflammation. Toxicology Letters 177:130

66.  X. Zhao, F. Li, J.R. Town, X. Zhang, W. Wang, and J.R. Gordon.  2007. Humanized forms of the CXCR1/CXCR2 antagonist, bovine CXCL8(3-74)K11R/G31P, effectively block ELR-CXC chemokine activity and airway endotoxemia pathology.  International Immunopharmacology 7:1723-31.

65. H. Wang, Q.H. Meng, J.R. Gordon, H. Khandwala, L. Wu.  2007. Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus.  Clinical Biochemistry 40:1232-9 

64. C. Ebeling, T. Lam, J.R. Gordon, M.D. Hollenberg, and H. Vliagoftis.  2007. Proteinase-Activated Receptor-2 Promotes Allergic Sensitization to an Inhaled Antigen through a TNF-Mediated Pathway.  Journal of Immunology 179:2910-2917. 

63. JL. Carmalt,  J.R. Gordon, A.L. Allen.  2006.  Temporomandibular joint cytokine profiles in the horse.  Journal of Veterinary Dentistry 23:83-8

62. F. Shahriar, M. Ngeleka, J.R. Gordon, and E. Simko. 2006.  Identification by affinity chromatography/mass spectroscopy of Escherichia coli lipopolysaccharide-binding proteins in porcine milk.  Canadian Journal of Veterinary Research 70:243-50  

61. F. Shahriar, M. Ngeleka, J.R. Gordon, and E. Simko.  2006.  Identification by mass spectroscopy of F4-fimbrial-binding proteins in porcine milk and characterization of lactadherin as an inhibitor of F4-positive Escherichia coli attachment to intestinal villi in vitro. Developmental and Comparative Immunology 30:723-34

60. J.R. Gordon, F. Li, X. Zhang, W. Wang, X. Zhao, and A. Nayyar.  2005.  The combined CXCR1/CXCR2 antagonist CXCL8(3-73)K11R/G31P blocks neutrophil infiltration, pyrexia and pulmonary vascular pathology in endotoxemic animals.  Journal of Leukocyte Biology 78: 1265-1272. 

59. X. Zhang, H. Huang, J. Yuan, D. Sun, W-S. Hou, J.R. Gordon, and Jim Xiang. 2005. CD4-8- dendritic cells prime CD4+ T regulatory 1 cells to suppress antitumor immunity.  Journal of Immunology 175: 2931-2937. 

58. C. Ebeling, P. Forsyth, P. Ng, J.R. Gordon, N. Hollenberg, and H. Vliagoftis.  2005.  Proteinase-activated receptor-2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways.  Journal of Allergy and Clinical Immunology 115: 623-30. 

57. J.R. Gordon, F Li, J. Xiang, and X. Zhang. 2005. Allergen-presenting splenic CD8a+ dendritic cells tolerize allergic lung disease via an IL-10-dependent, contact-independent, mechanism. Journal of Immunology 175: 1516-1522.

56. P. Forsythe, C. Ebeling, JR. Gordon, AD Befus and H Vliagoftis.  2004.  Opposing effects of short and long term stress on airway inflammation. American Journal of Respiratory and Critical Care Medicine 169:220-26.

Books, Books chapters & review Articles

11.  X. Zhang, J.R. Gordon, J. Xiang, 2002.  Advances in Dendritic Cell-Based Vaccines for Cancer.  Cancer Biotherapy and Radiopharmacology 17:601-619.

10.  J. Xiang and J.R. Gordon, 2002.  Genetic Engineering of a Recombinant Fusion Protein Possessing an Anti-Tumor Antibody Fragment and a TNF-" Moiety.  In Methods in Molecular Medicine.  W. Kiess, D. Korhoz and A. Kosser (eds). Humana Press Inc, Totowa, NJ.  pp 201-12.

9.  J.R. Gordon, 1997.  FceRI-Induced Cytokine Production and Gene Expression. In: IgE Receptor (FceRI) Function in Mast Cells and Basophils.  M.M. Hamaway (ed.), R.G. Landes, Austin, Texas. pp 209-242.

8.  S.J. Galli, J.R. Gordon, B.K. Wershil, A. Elovic, D.T.W. Wong, P.F. Weller, 1994.  Mast Cell and Eosinophil Cytokines in Allergy and Inflammation. In: Gleich, G.J., Kay A.B., eds. Eosinophils: Immunological and Clinical Aspects, pp. 255-280. New York: Marcel Decker.

7.  J.R. Gordon, and S.J. Galli, 1992. Mast Cells: Sources of Multifunctional Cytokines. In: Dammacco, F.(ed.), Advances in Tumor Immunology and Allergic Disorders, pp. 165-186.  London: Springer International.

6.  S.J. Galli, M. Tsai, J.R. Gordon, E.N. Geissler, T.R. Martin, and B.K. Wershil, 1992.  Analyzing Mast Cell Development and Function Using Mice Carrying Mutations at W/c-kit or SI/MGF (SCF) Loci.  Annals of the New York Academy of Sciences, 664: 69-88.

5.  S.J. Galli, E.N. Geissler, B.K. Wershil, J.R. Gordon, M. Tsai, M. and I. Hammel, 1992. Insights into Mast Cell Development and Function Derived from Analyses of Mice Carrying Mutations at Beige, W/c-kit or SI/SCF (c-kit ligand) loci.  In: Kaliner, M.A. and Metcalfe, D.D., eds. The Role of the Mast Cell in Health and Disease.  New York: Marcel Dekker, pp. 129-202.

4.  S.J. Galli, J.R. Gordon, and B.K. Wershil, 1991.  Cytokine Production by Mast Cells and Basophils.  Current Opinions in Immunology, 3: 865-873.

3.  J.R. Gordon, P.R. Burd, S.J. Galli, 1990.  Mast Cells as a Source of Multifunctional Cytokines.  Immunology Today, 11, 458-464.  (Invited Review)

2.  S.J. Galli, B.K. Wershil, H. Yano, N. Arizono, J.R. Gordon, T. Murakami, 1989.  Analysis of the Roles of Phenotypically Distinct Mast Cell Populations in Non-Immunological Responses.  In S.J. Galli and K.F. Austen, (ed.), Mast Cell and Basophil Differentiation in Health and Disease, pp. 255-274.  Raven Press.

1.  S.J. Galli, B.K. Wershil, J.R. Gordon, T.R. Martin, 1989.  Mast Cells: Immunologically Specific Effectors and Potential Sources of Multiple Cytokines During IgE-Dependent Responses.  In H. Metzger, (ed.), IgE, Mast Cells and the Allergic Response, pp. 53-73.  Ciba Foundation Symposium #147.

Research Grants:

Principle Investigator: Last 6 years

2009-11 Saskatchewan Health Research Foundation Group Development Grant.  Airways Research Group.  $100,000.

2008-13 CIHR operating grant. Mechanisms mediating the effects of tolerogenic dendritic cells.  $675,000.

2008 CIHR Symposium/Workshop Grant (two institutes). The Sixth International Symposium: Public Health and the Agricultural Rural Ecosystem.  Oct 19-23, 2008 (Saskatoon, SK). $20,000.

2008-09 NSERC Discovery Grant extension. ELR-CXC chemokines in bacterial inflammation.  $30,000.

2008 Canadian Agricultural Safety Association Knowledge Translation program (three independent grants) Swine Workers Resource; Saskatchewan Agricultural Producers Day; and Saskatchewan Farm Safety Radio Messages.  $29,500

2008 National Institute for Occupational Safety and Health (U.S.) grant. The Sixth International Symposium: Public Health and the Agricultural Rural Ecosystem. Oct 19-23, 2008 (Saskatoon, SK). $54,000

2007 CIHR Symposium/Workshop Grant. (two symposia) Canadian Society for Immunology Annual meeting, Mar 15-18, 2007 (Chateau Lk Louise, Alberta). $7,000.

2006-07 CIHR Proof of Principle – phase II grant (industry-matching). Mechanisms and indications for a human ELR-CXC chemokine antagonist.  $250,000.

2006 Research contract with Pacgen Biopharmaceuticals/IL Therapeutics – Indications assessments for the ELR-CXC chemokine antagonist, human CXCL8(3-73)K11R/G31P.   $117,000.

2006-07 NSERC Research Tools and Instruments.  Microplate spectrofluorimeter.  $70,000 (matching grant).

2005-08 CIHR operating grant. Mechanisms mediating tolerogenic dendritic cell therapy in allergic asthma.  $338,175.

2005-08 NSERC Discovery Grant. ELR-CXC chemokines in bacterial inflammation.  $90,000.

2004-05 Research contract with IL Therapeutics Inc. - Humanization of the CXCR1/ CXCR2 antagonist, bovine CXCL8(3-74)K11R/G31P. $186,000.

2002-05 CIHR operating grant. Therapeutic immunomodulation by use of dendritic cells in allergic asthma.  $218,000

2000-02 Saskatchewan Lung Association/Canadian Thoracic Society.  “Development of an effective Th2-reversing allergen-adjuvant immunotherapy for treatment of allergic lung disease.”  $60,000

Co-applicant: Last 3 years

2009-15. J. Dosman, J.R. Gordon & P. Pahwa.  CIHR Operating Grant.  Saskatchewan Rural Health Study. $1.7M 

2007-09. J Marshall (& 8 others; Gordon, co-applicant).  AllerGen NCE strategic funds grant. Canadian Group on Food Allergy Research (CanGoFAR).  $740,000

2007-11. J. Dosman (& 7 others; Gordon, co-PI).  CFI New Initiatives Fund. Canadian Centre for Health and Safety in Agriculture: National Agricultural Industrial Hygiene Laboratory. $14.6M (CFI contribution, $5.8M) 

2006-08. A. Rosenberg (& 7 others; Gordon, co-PI).  CIHR New Emerging Team grant. Biologically-based outcome predictors in juvenile idiopathic arthritis.  $202,000

2006-08. J.R. Gordon and P.A. Bretscher.  Saskatchewan Health Research Foundation Research Group Development Grant.  Immunology and Infectious Diseases Research Group Core Funding.  $100,000

2006-’08.  M Mayer, J.R. Gordon & H Huang.  WCVM Companion Animal Health Research Fund.  Dendritic cell vaccination against oral melanoma tumours in dogs.  $13,500

2005-06.  Mario Jacques (Leader) & 11 others.  NSERC Research Management Fund Grant. Canadian Swine Infectious Diseases Network (SIDNet).  $100,000

2005-07.  J. Marshall (& 7 others; Gordon, co-PI).  AllerGEN (CIHR National Centre of Excellence) Strategic Grant.  Functional consequences of allergic disease-associated polymorphisms in innate immune receptor systems. $160,000.

2005-06.  A. Livingston, JR Gordon.  WCVM Companion Animal Health Fund Grant.  Effect of chronic opioids on immune response in dogs.  $14,088.

2004-06. J.R. Gordon and P.A. Bretscher.  Saskatchewan Health Research Foundation Health Research Groups Facilitation Grant. University of Saskatchewan Immunology and Infectious Diseases Research Group.  $100,000